EFFECT OF CHRONIC EXPOSURE AND NON-RADIATION FACTORS ON THE INTRACELLULAR STAT3 CONCENTRATION

Purpose: To evaluate the influence of radiation and non-radiation factors on intracellular concentration transcription factor STAT3 in peripheral blood lymphocytes chronically irradiated residents coastal villages Techa River long-term after onset irradiation. Material methods: The main group consisted 50 people aged 67 to 84 years old with an average dose irradiation red bone marrow 727.9±79.1 mGy; thymus lymphoid organs – 85.9±13.6 mGy. comparison included 25 from 61 87 who were not exposed accidents, whose distribution by sex ethnicity corresponded composition group. Peripheral lymphocyte lysates normalized for total protein prior enzyme immunoassay. Results: median was 167.6 (118.3–240.1) pg/ml 147.0 (116.7–179.2) control Conclusion: level did differ significantly between non-exposed individuals, as well different subgroups. Correlations characteristics, gender examined found. In a 0.85 Gy or more, correlated age at time examination (SR= ‒0.67, p=0.01). other subgroups, no correlation found estimated indicator achieved age. results are preliminary.